14
Comparison
of overall reactions
Gluconeogenesis:
•2
pyruvate + 4 ATP + 2 GTP + 2 NADH + 2 H2O ----> glucose + 4 ADP + 2 GDP + 2
NAD+ + 6 Pi DG = - 37.6 kJ/mole
•Glycolysis:
•glucose
+ 2 ADP + 2 Pi + 2 NAD+ ----> 2 pyruvate + 2 ATP + 2 NADH + 2 H2O
DG = -83.7 kJ/mole = glycolysis or +83.7 kJ/mole if gluconeogenesis were the reverse of glycolysis (clearly, this can't happen)
DG = -83.7 kJ/mole = glycolysis or +83.7 kJ/mole if gluconeogenesis were the reverse of glycolysis (clearly, this can't happen)
•There
is a loss of 4 moles of ATP/mole of glucose made by
gluconeogenesis.