•Catabolism of Glucose through Glycolysis and the
Krebs Cycle
•Each molecule of Glucose produces two molecules of
Pyruvate
•Glucose
+ 2NAD+ + 2ADP + 2Pi ð 2Pyruvate + 2NADH + 2H+ + 2H2O +2ATP
•Action of Pyruvate
Dehydrogenase on Pyruvate:
•Pyruvate
+ CoA-SH + NAD+ ð CO2 +
Acetyl-CoA + NADH
•The overall catabolism
of Glucose to 2 Pyruvate molecules:
•Glucose
+ 2NAD+ + 2ADP + 2Pi ð 2Pyruvate + 2NADH + 2H+ +
2H2O +2ATP 2Pyruvate + 2CoA-SH + 2NAD+ ð 2CO2 + 2Acetyl-CoA + 2NADH •Glucose + 4NAD+ + 2ADP + 2CoA-SH + 2Pi ð 2CO2 + 2Acetyl- CoA + 4NADH + 2H+ + 2H2O +2ATP •The GTP formed in the animal Succinyl-CoA Synthetase reaction in the Krebs cycle is readily converted to ATP (by Nucleoside Diphosphokinase)