•Acetyl-CoA + Oxaloacetate + H2O ð Citrate + CoA-SH + H+
•Citrateó cis-Aconitate + H2O
•cis-Aconitase
+ H2O ó Isocitrate
•isocitrate
+ NAD+ ó a-Ketoglutarate + CO2 + NADH
•a-Ketoglutarate + NAD+ + CoA-SH ó Succinyl-CoA + CO2 + NADH
•Succinyl-CoA + Pi + GDP ó Succinate + GTP + CoA-SH
•Succinate + E-FAD ó Fumarate + E-FADH2
•Fumarate
+ H2O ó L-Malate
•L-Malate
+ NAD+ ó Oxaloacetate + NADH
+ H+
•Acetyl-CoA + 2H2O +
3NAD+ + Pi + GDP + FAD ð 2CO2 + 3NADH + GTP + CoA-SH + FADH2 + 2H+